Research
MHFP Research
The Margaret Hackett Family Program (MHFP) supports and engages in research dedicated to improving treatments and bettering surgical outcomes for patients with CNS congenital anomalies.
MHFP Database
The primary goal of the Margaret Hackett Family Program (MHFP) Database is to gather comprehensive patient medical histories into a database to monitor and store information that may be helpful in bettering patient care. The MHFP Database uses REDCap to collect extensive information about patient symptoms, treatments, and surgical history. By collecting this information, the MHFP and its collaborating institutions will have access to data that may help better understand and improve patient treatments and surgical outcomes. Current collaborating sites are located in Los Angeles, CA, Boston, MA, and Charlotte, NC.
MEET SEIF GHOLAMPOUR
Research Professional, MHFP
Dr. Seif Gholampour currently works for the Margaret Hackett
Family Program in the Department of Neurological Surgery at
the University of Chicago. He has more than 13 years of
research experience in biomedical modeling of CNS,
computational and experimental neuroscience, cerebral blood
hemodynamics, CSF hydrodynamics, machine learning, brain
morphology, brain biomechanics, image-based fluid-structure
interaction/computational fluid dynamics/finite element
analysis simulations in neuroscience, and neurosurgical drilling
systems.
MEET JESSE HUANG
Clinical Research Analyst, MHFP
Jesse recently graduated from the Johns Hopkins
University, where he earned dual degrees in Biophysics
and Applied Math & Statistics. During his studies, Jesse
also worked as a research assistant focusing on
neurodegenerative diseases at the Johns Hopkins Medical
Institute, where he developed an interest in medicine
involving the brain. Currently, he hopes to be able to
explore the field of neurosurgery through clinical
research at the Margaret Hackett Family Program and
plans on applying to medical school in the near future.
Articles
The Margaret Hackett Family Program (MHFP) supports and engages in research dedicated to improving treatments and bettering surgical outcomes for patients with CNS congenital anomalies. Learn more about the MHFP’s research below.
Perioperative Complications Following Spine Surgery in Adult Patients with Achondroplasia
Skeletal dysplasias, or osteochondroplasias, encompass hundreds of disorders which affect the growth, development, and maturity of bone and cartilaginous structures. The most common of these is achondroplasia which occurs in around 1/25,000 births.
How We Predict and Improve Shunt Outcomes? Cerebrospinal Fluid Hydrocephalus Shunting
Cerebrospinal fluid shunt failure in patients with hydrocephalus is a complex process. This study aims to use the MHFP database to evaluate various factors that regulate shunt outcomes.
Hydrocephalus: Can Intracranial Compliance Predict Clinical Oscillations?
The impact of this study can gain insight into the quantitative evaluation of material property and relaxation behavior of brain tissue and their relationships with diagnosis, prognosis, and management of hydrocephalus patients.
Special Considerations in Pediatric Endoscopic Skull Base Surgery
Originally pioneered in adults, endoscopic endonasal approaches for skull base pathology are being increasingly applied as a minimally invasive alternative for young children.
Questions to Solve When Blood, Brain & Cerebrospinal Fluid Interact
This study tries to understand the interaction of cerebral blood and cerebrospinal fluid with brain tissue to alleviate the pathophysiological ambiguities in cerebrospinal fluid dyscrasia.
Skull Base Drilling: How Coolants Can Reduce Thermal & Physical Damage?
This project will study novel gas coolants to decrease the risk of thermal death in cells of the skull, blood coagulation, adjacent nerves injury, and micro-fractures during skull base drilling.